Presentation of new clinical data for KidneyIntelX
KidneyIntelXTM Clinical Results Presented at World Congress of Nephrology Demonstrate Improved Prediction of Kidney Function Over Standard of Care
Data highlights strength of KidneyIntelX for clinical use in early-stage diabetic kidney disease patients beyond commonly used markers UACR and historical eGFR change over time
Advanced risk assessment tools, such as KidneyIntelX, enable primary care physicians to make optimized treatment decisions through accurate determination of individual patient risk and provide the opportunity to change intensity of care management based on that risk. In the short term, KidneyIntelX can more efficiently assess the integrated impact of changes in key risk factors (glucose, blood pressure, and albuminuria) on overall kidney health, which often do not manifest in kidney function improvements for several years.
"The key takeaway is that historical measurements commonly used today to understand kidney disease do not provide a clear picture of the future," said
The data results presented also showed the ability to use KidneyIntelX in conjunction with clinical features to reinforce the beneficial effects of new therapeutics in the same population.
"Enabling optimal pharmacy management via KidneyIntelX may ultimately decrease hospital admissions, emergency room visits, dialysis and kidney failure risks," said
KidneyIntelX is the only early-stage, bioprognostic solution for kidney health, and has received Breakthrough Device Designation from the
2022
Highlights from the abstracts are as follows:
Abstract WCN22-0561: "Added Value of KidneyIntelX for Predicting Future Kidney Function Decline Compared with Historical eGFR Trajectories"
· Traditional kidney metrics, such as high albuminuria or low estimated eGFR, or historical rate of eGFR decline, do not adequately determine "future progression" of kidney disease
· The independent prognostic value of KidneyIntelX was assessed for future outcomes above and beyond traditional kidney metrics
· The KidneyIntelX risk score provided robust prognostic information for future eGFR trajectories and adverse kidney outcomes beyond ascertainment of baseline kidney function, glomerular injury, or historical kidney function trajectories
· This shows additional utility of KidneyIntelX for clinical care risk stratification and enrichment for clinical trials beyond commonly used measures
Abstract WCN22-0564: "
· Prior analyses from the CANVAS trial cohort have shown that changes in a patient's KidneyIntelX score over time were informative of prognosis above and beyond the baseline KidneyIntelX score
· The associations between changes in common clinical treatment targets such as systolic blood pressure (SBP), HbA1c, and UACR with early improvements in kidney health, as measured by KidneyIntelX, were not previously explored
· Longitudinal improvements to target SBP, HbA1c and UACR resulted in meaningful and robust changes in the KidneyIntelX risk score, particularly in individuals randomized to canagliflozin, in this post hoc analysis
· In sum, these data suggest that KidneyIntelX can be used in conjunction with clinical features to reinforce the beneficial effects accrued from the treatments in patients with DKD
For further information, please contact:
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Via Walbrook PR |
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Stifel (Nominated Adviser, Joint Broker) |
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Tel: 020 7597 4000 |
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Tel: 020 7933 8780 or renalytix@walbrookpr.com |
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Mob: 07980 541 893 / 07584 391 303 / 07407 804 654 |
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Tel: 415-389-6400 or investors@renalytix.com |
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About Kidney Disease
Kidney disease is now recognized as a public health epidemic affecting over 850 million people globally. The
About Renalytix
About KidneyIntelX
KidneyIntelX, is a first-of-kind solution that enables early-stage diabetic kidney diseases (DKD) progression risk assessment by combining diverse data inputs, including validated blood-based biomarkers, inherited genetics, and personalized patient data from electronic health record, or EHR, systems, and employs a proprietary algorithm to generate a unique patient risk score. This patient risk score enables prediction of progressive kidney function decline in CKD, allowing physicians and healthcare systems to optimize the allocation of treatments and clinical resources to patients at highest risk.
Sources
1. https://www.cdc.gov/kidneydisease/publications-resources/ckd-national-facts.html
2. https://www.nicresearch.com/clinical-research-necessary-nephrology/
3. https://optn.transplant.hrsa.gov/
Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Examples of these forward-looking statements include statements concerning: the potential benefits, including economic savings, of KidneyIntelX, the potential for KidneyIntelX to receive regulatory approval from the FDA, the commercial prospects of KidneyIntelX, if approved, including whether KidneyIntelX will be successfully adopted by physicians and distributed and marketed, our expectations regarding reimbursement decisions and the ability of KidneyIntelX to curtail costs of chronic and end-stage kidney disease, optimize care delivery and improve patient outcomes. Words such as "anticipates," "believes," "estimates," "expects," "intends," "plans," "seeks," and similar expressions are intended to identify forward-looking statements. We may not actually achieve the plans and objectives disclosed in the forward-looking statements, and you should not place undue reliance on our forward-looking statements. Any forward-looking statements are based on management's current views and assumptions and involve risks and uncertainties that could cause actual results, performance or events to differ materially from those expressed or implied in such statements. These risks and uncertainties include, among others: that KidneyIntelX is based on novel artificial intelligence technologies that are rapidly evolving and potential acceptance, utility and clinical practice remains uncertain; we have only recently commercially launched KidneyIntelX; and risks relating to the impact on our business of the COVID-19 pandemic or similar public health crises. These and other risks are described more fully in our filings with the
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