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Holding(s) in Company

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Renalytix plc

(“Renalytix” or the “Company”)

Holding(s) in Company

LONDON and NEW YORK, 16 October 2025 – Renalytix plc (LSE: RENX) (OTCQB: RNLXY), announces that it has received a TR-1 notification from Harwood Capital LLP following the recent admission of ordinary shares and increase in the Company’s total issued share capital (RNS 8264C: $4m balance sheet improvement with bond conversion). The resulting crossing of a threshold is due to an increase in the Company’s total issued share capital, rather than any disposal or acquisition of shares. The TR-1 notification is reproduced below.

1. Issuer Details

ISIN

GB00BYWL4Y04

Issuer Name

RENALYTIX PLC

UK or Non-UK Issuer

UK

2. Reason for Notification

An event changing the breakdown of voting rights

3. Details of person subject to the notification obligation

Name

Harwood Capital LLP

City of registered office (if applicable)

Country of registered office (if applicable)

Name

City of registered office

Country of registered office

Harwood Capital Management (Gibraltar) Limited

Gibraltar

Gibraltar

Harwood Capital LLP

London

United Kingdom

4. Details of the shareholder

Name

City of registered office

Country of registered office

North Atlantic Smaller Companies Investment Trust Plc

London

United Kingdom

Oryx International Growth Fund Limited

Guernsey

Guernsey

Harwood Capital LLP

London

United Kingdom

5. Date on which the threshold was crossed or reached

15-Oct-2025

6. Date on which Issuer notified

15-Oct-2025

7. Total positions of person(s) subject to the notification obligation

% of voting rights attached to shares (total of 8.A)

% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)

Total of both in % (8.A + 8.B)

Total number of voting rights held in issuer

Resulting situation on the date on which threshold was crossed or reached

3.903000

0.000000

3.903000

17061345

Position of previous notification (if applicable)

4.411130

0.000000

4.411130


8. Notified details of the resulting situation on the date on which the threshold was crossed or reached

8A. Voting rights attached to shares

Class/Type of shares ISIN code(if possible)

Number of direct voting rights (DTR5.1)

Number of indirect voting rights (DTR5.2.1)

% of direct voting rights (DTR5.1)

% of indirect voting rights (DTR5.2.1)

GB00BYWL4Y04

11500000


2.631000


GB00BYWL4Y04

4800000


1.098000


GB00BYWL4Y04

761345


0.174000


Sub Total 8.A

17061345

3.903000%

8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))

Type of financial instrument

Expiration date

Exercise/conversion period

Number of voting rights that may be acquired if the instrument is exercised/converted

% of voting rights





Sub Total 8.B1




8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))

Type of financial instrument

Expiration date

Exercise/conversion period

Physical or cash settlement

Number of voting rights

% of voting rights






Sub Total 8.B2




9. Information in relation to the person subject to the notification obligation

2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)

Ultimate controlling person

Name of controlled undertaking

% of voting rights if it equals or is higher than the notifiable threshold

% of voting rights through financial instruments if it equals or is higher than the notifiable threshold

Total of both if it equals or is higher than the notifiable threshold

Christopher Harwood Bernard Mills

North Atlantic Smaller Companies Investment Trust Plc

2.631000


2.631000%

Christopher Harwood Bernard Mills

Oryx International Growth Fund Limited

1.098000


1.098000%

Christopher Harwood Bernard Mills

Harwood Capital LLP

0.174000


0.174000%

10. In case of proxy voting

Name of the proxy holder

The number and % of voting rights held

The date until which the voting rights will be held

11. Additional Information

12. Date of Completion

15/10/2025

13. Place Of Completion

London Stock Exchange

For further information, please contact:

Renalytix plc

www.renalytix.com

James McCullough, CEO

Via Walbrook PR



SP Angel Corporate Finance LLP (Nominated Adviser and Joint Broker)

Tel: +44 (0)20 3470 0470

Jeff Keating / David Hignell (Corporate Finance)

Vadim Alexandre (Corporate Broking)




Oberon Capital (Joint Broker)

Tel: +44 (0)20 3179 5300

Mike Seabrook / Nick Lovering




Walbrook PR Limited

Tel: 020 7933 8780 or [email protected]

Paul McManus / Alice Woodings

Mob: 07980 541 893 / 07407 804 654

About Renalytix ( www.renalytix.com )

Renalytix (LSE: RENX) (OTCQB: RNLXY) is an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes. Renalytix has received FDA approval and Medicare reimbursement for kidneyintelX.dkd which is now offered commercially in the United States.

Unrecognized and uncontrolled kidney disease remains one of the largest barriers to controlling cost and suffering in the United States and the United Kingdom’s medical system, affecting over 14 million and 8 million people, respectively. After five years of development and clinical validation, kidneyintelX.dkd is the only FDA-approved and Medicare reimbursed prognostic tool capable of understanding a patient’s risk with kidney disease early where treatment has maximal effect. kidneyintelX.dkd is now being deployed across large physician group practices and health systems in select regions of the United States.

The over 15,000 patients that have been tested by kidneyintelX.dkd have produced a substantial body of real-world performance data. In patient populations where kidneyintelX.dkd has been deployed, a demonstrated and significant increase in diagnosis, prognosis, and treatment rates have been recorded. kidneyintelX.dkd now has full reimbursement established by Medicare, the largest insurance payer in the United States, at $950 per reportable result. kidneyintelX.dkd is also recommended for use in the international chronic kidney disease clinical guidelines (KDIGO).

KidneyIntelX is based on technology developed by Mount Sinai faculty and licensed to Renalytix AI, Inc. Mount Sinai faculty members are co-founders and equity owners in the Company. In addition, the Icahn School of Medicine at Mount Sinai has equity ownership in Renalytix. For information about the kidneyintelX.dkd test, visit kidneyintelx.com .